Status of certain additional over-the counter drug category II and III active ingredients. View abstract. Low potassium levels can increase the risk of side effects of digoxin (Lanoxin). Metabolic effects of aloe vera gel complex in obese prediabetes and early non-treated diabetic patients: randomized controlled trial. Melanoma Res 2005;15(6):489-494. Investigation of the anti-inflammatory potential of Aloe vera gel (97.5%) in the ultraviolet erythema test. CONDITIONS OF USE AND IMPORTANT INFORMATION: 2010;24:168-72. View abstract. Zhong.Yao Cai. View abstract. Aloe vera helps ulcerative colitis. Eur J Cancer 1998;34:1091-8. Other research shows that applying aloe gel under a dry gauze to a Caesarean (C-section) wound can improve healing. Hegazy SK, El-Bedewy M, Yagi A. Antifibrotic effect of aloe vera in viral infection-induced hepatic periportal fibrosis. J Derm Treatment 1999;10(1):7-11. View abstract. Respir.Res 2011;12:92. View abstract. Randomized trial of aloe vera gel vs triamcinolone acetonide ointment in the treatment of oral lichen planus. View abstract. Int J Dermatol. Phytomed 1996;3(3):245-248. View abstract. 2016 Apr;41(2):180-8. Esua, M. F. and Rauwald, J. W. Novel bioactive maloyl glucans from aloe vera gel: isolation, structure elucidation and in vitro bioassays. A double-blind clinical study in humans. View abstract. Effects of oral Aloe vera on electrocardiographic and blood pressure measurements. View abstract. View abstract. Early research suggests that applying a cream containing aloe gel and olive oil three times daily for 10 days reduces the severity of diaper rash in children younger than 3-years-old. Langmead L, Makins RJ, Rampton DS. 1994;17:495-7. Preliminary study of effectiveness of aloe vera in scabies treatment. Some creams for minor burns have just 0.5% aloe vera. 2009;20(8):1445-1446. Plemons J, Rees TD Binnie WH Wright JM. View abstract. View abstract. Tanaka M, Yamamoto Y, Misawa E, et al. 2012;2:CD008762. B. Studies of aloe. Early research suggests that applying an aloe cream three times daily for at least 3 weeks can improve pain and wound healing in people with this condition. Applies to phytonadione: capsule, tablet. Cheng S, Kirtschig G, Cooper S, et al. Plast Reconstr Surg. In comparison to a lot of fruit and vegetables, the vitamin content of aloe vera is relatively low; however, the vitamin content in aloe is crucial for the synergy effect of all of the other ingredients. It is cultivated for agricultural and medicinal uses. When taken by mouth aloe latex is a laxative. View abstract. Aloe gel might decrease blood sugar. It does more than just leave skin soft, however. A placebo-controlled, double-blind, comparative study. View abstract. Proponents claim that aloe vera can even speed the healing of wounds and reduce the severity of psoriasis. Shoji, A. Ishii Y, Tanizawa H, Takino Y. Wounds 2018;30(9):263-8. Horm.Res. Some research also shows that applying aloe cream reduces wound size compared to applying, Diabetes. View abstract. 2008;8(2):78-81. View abstract. Other research evaluating a specific aloe-containing toothpaste (Forever Bright, Forever Living Products) shows that it works about as well as a toothpaste that contains fluoride. 2009;144(1):85-91. Effect of Aloe vera topical gel combined with tretinoin in treatment of mild and moderate acne vulgaris: a randomized, double-blind, prospective trial. Skin lotions and topical anti-inflammatory treatments tout aloe vera as a healing and soothing wonder gel. The effects of aloe vera on wound healing in cell proliferation, migration, and viability. Retardation of wound healing by silver sulfadiazine is reversed by Aloe vera and nystatin. Stimulant laxatives can decrease potassium levels in the body. View abstract. NIH states that diarrhea can increase the effects of Coumadin, which can increase your risk of bleeding. View abstract. 2007;(4):CD000978. View abstract. View abstract. View abstract. Beppu H, Nagamura Y, and Fujita K. Hypoglycemic and antidiabetic effects in mice of aloe-arborescens miller var natalensis berger. 2009;23:171-5. Clinical and toxicological aspects of anthraquinone laxatives. Alvarez-Perea, A., Garcia, A. P., Hernandez, A. L., de, Barrio M., and Baeza, M. L. Urticaria due to aloe vera: a new sensitizer? View abstract. 1986;24(4):288-294. The dose of your diabetes medication might need to be changed. View abstract. Clin Research 1987;35(3):483a. 2020;48:102233. View abstract. The efficacy of oral Aloe vera for radiation induced mucositis in head and neck cancer patients: a double-blind placebo controlled study. Evaluation of the efficacy of two mouthrinses formulated for the relief of xerostomia of diverse origin in adult subjects. View abstract. 1976;14 Suppl 1:73-7. Honig J, Geck P, and Rauwald HW. What Are the Benefits of Applying CoQ10 to the Skin. Aloe vera in the treatment of radiation ulcers of mucous membranes. 2009;39:587-91. Skin Pharmacol Physiol. Lin, J. G., Chen, G. W., Li, T. M., Chouh, S. T., Tan, T. W., and Chung, J. G. Aloe-emodin induces apoptosis in T24 human bladder cancer cells through the p53 dependent apoptotic pathway. 2008;16:293-6. Early research shows that applying aloe to the skin might help skin survive frostbite injury. Aloe vera is rich in several minerals which makes it unique. Shah, S. A., DiTullio, P., Azadi, M., Shapiro, R. J., Eid, T. J., and Snyder, J. This information may not fit your specific health circumstances. Other studies have shown that taking aloe can make vitamin B12 more bioavailable, meaning the body can more easily absorb and utilize it, thereby helping to prevent deficiency. Some research shows that applying an aloe cream to hemorrhoid-related wounds can help the wounds heal and provide some pain relief. Morrow, D. M., Rapaport, M. J., and Strick, R. A. Hypersensitivity to aloe. Photodermatol. Wounds 1995;7(5):200-202. Baretta, Z., Ghiotto, C., Marino, D., and Jirillo, A. Aloe-induced hypokalemia in a patient with breast cancer during chemotherapy. View abstract. Interventions for preventing oral mucositis for patients with cancer receiving treatment. One can break open the plant leaf and apply the natural gel directly onto the skin, or one can buy the gel in lotions and creams for topical treatment. Often extolled for its soothing qualities, aloe vera is most commonly used as a topical ointment for burns, sun damage, and skin abrasions, but this ancient plant may offer deeper healing abilities when taken orally. active substances in the gel are glycoproteins and polysaccharides Albeit you should be patient with your results, within a few months of daily application, you … Diaper rash. No doi. Evaluation of the anti-angiogenic effect of aloe-emodin. J Dermatol. [Letter.]. Successful treatment of acute radiation proctitis with aloe vera: a preliminary randomized controlled clinical trial. Wounds 1994;6(2):4. Other dosage forms: injection emulsion, injection solution; Side effects requiring immediate medical attention Canker sores. Br J Dermatol 2008;158(3):573-577. View abstract. Eshghi F, Hosseinimehr SJ, Rahmani N, et al. J.Oral Pathol.Med. Sevoflurane also decreases clotting of the blood. The effect of aloe vera and tea tree oil mouthwashes on the oral health of school children. Journal of the European Academy of Dermatology & Venerology 1996;7:294-95. Dannemann, K., Hecker, W., Haberland, H., Herbst, A., Galler, A., Schafer, T., Brahler, E., Kiess, W., and Kapellen, T. M. Use of complementary and alternative medicine in children with type 1 diabetes mellitus - prevalence, patterns of use, and costs. There have also been testimonies of aloe vera gel being drying to hair, that it contains protein which makes low-porosity hair stiff and dry, and many questions of whether or not it behaves as a humectant. 2004 Sep 1;60:171-7. extract on symptoms, fecal microbiota and fecal metabolite profiles in patients with irritable bowel syndrome. Bunyapraphatsara N, Yongchaiyudha S, Rungpitarangsi V, Chokechaijaroenporn O. Antidiabetic activity of Aloe vera L juice. Asian Biomedicine 2009;3(4):375-382. Some research shows that taking aloe might help with symptoms of IBS. Aloe vera is also a source of vitamins A, C, E, folic acid, choline, B1, B2, B3 (niacin), and B6. Merchant TE, Bosley C, Smith J, et al. View abstract. Early research suggests that applying a cream containing aloe extract to the skin for 2 weeks increases the amount of water in the outermost layer of the skin. Rev Enferm. Fogleman, R. W., Chapdelaine, J. M., Carpenter, R. H., and McAnalley, B. H. Toxicologic evaluation of injectable acemannan in the mouse, rat and dog. Oncol Nurs Forum 2001;28:543-7. J Eur Acad Dermatol Venereol 1996;7:294-295. Asian Biomedicine 2009;3(4):375-382. Planta Med. When you drink aloe juice, it works like a stimulant laxative by increasing the contractions of your bowel muscles and … Phillips T, Ongenae K Kanj L Slater-Freedberg J. Euforia-induced acute hepatitis in a patient with scleroderma. Often extolled for its soothing qualities, aloe vera is most commonly used as a topical ointment for burns, sun damage, and skin abrasions, but this ancient plant may offer deeper healing abilities when taken orally. Early research suggests that some people with mild to moderate ulcerative colitis who take aloe gel by mouth for 4 weeks have significantly reduced symptoms. 1996;55(1):69-75. Some research shows that applying a gel containing aloe to the gums after getting dental appliances helps to prevent mouth sores. Ann Pharmacother 2004;38:1651-4. Also, other research suggests that applying aloe gel does not seem to delay new canker sores. Some early research also shows that using a mouth wash containing aloe reduces plaque in adolescents. Collins EE and Collins C. Roentgen dermatitis treated with fresh whole leaf of aloe vera. Apply at night, making sure to remove in the morning since it can cause sensitivity when exposed to the sun. Olatunya OS, Olatunya AM, Anyabolu HC, et al. Visuthikosol V, Chowchuen B, Sukwanarat Y, et al. Aloe vera dermal wound gel is associated with a delay in wound healing. Interventions for preventing oral mucositis for patients with cancer receiving treatment. Cochrane Database Syst Rev. Some early research suggests that using a toothpaste containing aloe daily for 24 weeks reduces plaque. Aliment Pharmacol Ther 2004;19:739-47. Some research even suggests that aloe might slow down wound healing. 2012;18:850-3. View abstract. View abstract. Cutis 1991;47(3):193-196. J.Eur.Acad.Dermatol.Venereol. Buckendahl J, Heukelbach J, Ariza L, et al. Some research shows that using a specific aloe-containing toothpaste (Forever Bright, Forever Living Products) is comparable to a toothpaste that contains fluoride at reducing gingivitis. Bottenberg MM, Wall GC, Harvey RL, Habib S. Oral aloe vera-induced hepatitis. Management of genital herpes in men with 0.5% Aloe vera extract in a hydrophilic cream. 2020. View abstract. Water pills (Diuretic drugs) interacts with ALOE. J Med Assoc Thai. Creams and gels with aloe vera vary in dosage. Oyelami OA, Onayemi A, Oyedeji OA, et al. Rowe TD, Lovell BK, and Parks LM. Aloe vera is conside… Some "water pills" that can decrease potassium include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDIURIL, Microzide), and others. J Coll Physicians Surg Pak. [Prevention of vascular ulcers and diabetic foot. View abstract. J Clin Epidemiol 1997;50(suppl 1):3S. 2011;11(2):142-148. Taking aloe latex along with "water pills" might decrease potassium in the body too much. 2005;24(4):438-442. Wang, Z. W., Huang, Z. S., Yang, A. P., Li, C. Y., Huang, H., Lin, X., Liu, Z. C., and Zhu, X. F. [Radioprotective effect of aloe polysaccharides on three non-tumor cell lines]. Rahmani N, Khademloo M, Vosoughi K, Assadpour S. Effects of Aloe vera cream on chronic anal fissure pain, wound healing and hemorrhaging upon defection: a prospective double blind clinical trial. Early research suggests that taking 400 mg of a chemical that comes from aloe four times daily does not improve immune function in people with human immunodeficiency virus (HIV). Worthington HV, Clarkson JE, Bryan G, et al. Early research shows that applying a specific product containing acemannan, a chemical from aloe, to the tooth socket after standard treatment reduces pain and improves symptoms from dry socket more than standard treatment alone. 1980;116(9):1064-1065. 2020;32(8):e13860. Mol Med Rep 2018;18(3):3537-43. doi: 10.3892/mmr.2018.9319. View abstract. Radiology 1939;32:598-599. Phytomedicine 1996;3:241-3. Sahebnasagh A, Ghasemi A, Akbari J, et al. Savchak VI. View abstract. Aloe vera is rich in several minerals which makes it unique. Montaner JS, Gill J, Singer J, et al. J Altern Complement Med 2010;16:647-50. J Med Food 2004;7:61-6. Fed Regist 2002;67:31125-7. Antidiabetic activity of Aloe vera L. juice. Rev.Bras.Enferm. Gallagher J, Gray M. Is aloe vera effective for healing chronic wounds? View abstract. Digestion. Rosca-Casian, O., Parvu, M., Vlase, L., and Tamas, M. Antifungal activity of Aloe vera leaves. The species is also used for decorative purposes and grows successfully indoors as a potted plant. 2008;17:1963-72. View abstract. 1973;12(1):68-73. Evaluation of acemannan in providing pain relief in patients with recurrent aphthous stomatitis. Kaufman T, Kalderon N, Ullmann Y, Berger J. Aloe vera gel hindered wound healing of experimental second-degree burns: a quantitative controlled study. View abstract. Most research shows that applying aloe gel or cream to the skin can reduce healing time in people with first- or second-degree burns. Curr Drug Discov Technol. View abstract. Clinical trial in diabetes mellitus patients in combination with glibenclamide. Effects of low-dose Aloe sterol supplementation on skin moisture, collagen score and objective or subjective symptoms: 12-week, double-blind, randomized controlled trial. Radiol Rev Chicago Med Recorder 1935;57(6):137-138. J Okla.Dent.Assoc 2002;92(3):40-43. Cutan Ocul Toxicol. If you take warfarin, do not to take excessive amounts of aloe latex. Chapman, D. D. and Pittelli, J. J. Double-blind comparison of alophen with its components for cathartic effects. Widespread dermatitis after topical treatment of chronic leg ulcers and stasis dermatitis. View abstract. View abstract. Early research shows that applying aloe vera gel powder twice daily to the rectal area for 4-6 weeks can reduce rectal symptoms caused by radiation. Learn more about its effects, the dosage to take, and more. Davis, R. H., Donato, J. J., Hartman, G. M., and Haas, R. C. Anti-inflammatory and wound healing activity of a growth substance in Aloe vera. Nusko G, Schneider B, Schneider I, et al. J.Drugs Dermatol. Najafian Y, Mazloum Z, Najaf Najafi M, Hamedi S, Mahjour M, Feyzabadi Z. Efficacy of Aloe vera/ Plantago major gel in diabetic foot ulcer: a randomized double-blind clinical trial. Among the standouts in aloe vera are calcium, the key component in bones, teeth and cell signaling; zinc, selenium and magnesium, all essential for as many as 300 metabolic functions; and chromium, which enhances the insulin that provides cells with energy. Gerodontology. Thamlikitkul V, Bunyapraphatsara N Riewpaiboon W Theerapong S Chantrakul C et al. J Dermatolog Treat 2014;25(2):123-9. View abstract. Syed, T. A., Ahmadpour, O. Contact Dermatitis 1982;8(3):164-167. Like most other B vitamins, B1 works on a number of systems. It has fatty acids, salicylic acid and hormones called auxins and gibberellins, all of which result in inflammation reversal. But it isn't clear if the benefits were from the aloe or the gloves. Ai.Zheng. When taken by mouth aloe latex is a laxative. Planta Med 1993;59:A689. J Oral Pathol Med. View abstract. The stimulation of postdermabrasion wound healing with stabilized aloe vera gel-polyethylene oxide dressing. The gel contains folic acid, which makes new cells and prevents birth defects. IV. 2006;29(10):25-30. Some research shows that using an aloe solution 2-3 times daily during radiation therapy or chemotherapy can make this condition less severe. Neurogastroenterol Motil. View abstract. In fact, aloe has also long been a folk treatment for many maladies, including constipation and skin disorders. J Altern.Complement Med. Ann Pharmacother 2007;41:1740-3. Toxicol Sci. Fogleman, R. W., Shellenberger, T. E., Balmer, M. F., Carpenter, R. H., and McAnalley, B. H. Subchronic oral administration of acemannan in the rat and dog. View abstract. Aloe vera extract 0.5% in a hydrophilic cream versus Aloe vera gel for the management of genital herpes in males. The Aloe Vera plant contains five B vitamins and Choline, which scientists have recently declared a “B” class vitamin.. B1- Thiamin. Clear Evidence of Carcinogenic Activity by a Whole-Leaf Extract of Aloe barbadensis Miller (Aloe vera) in F344/N Rats. 2003;31:40-2. From relieving heartburn to potentially slowing the spread of breast cancer, researchers are just beginning to unlock the benefits of this universal plant and its many byproducts. Minerals: As vitamins are organic substance needed by our body, minerals are inorganic ones. Swelling (inflammation) of the liver (hepatitis). This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Miller MB, Koltai PJ. J Altern Complement Med. Kaya GS, Yapici G, Savas Z, et al. Aloe vera gel absorbs easily, making it ideal for oily skin. Nutrients 2016 Jun 23;8(7). When taken orally as a juice or dietary supplement, aloe vera's laxative effects can help ease constipation. Klein AD, Penneys NS. 2008;18:612-4. Mechanism of cathartic effect. View abstract. Lyon, France: International Agency for Research on Cancer; 2015. View abstract. Phytomedicine. Further observations on the use of Aloe vera leaf in the treatment of third degree x-ray reactions. Wu, J. H., Xu, C., Shan, C. Y., and Tan, R. X. Antioxidant properties and PC12 cell protective effects of APS-1, a polysaccharide from Aloe vera var. Note: This document contains side effect information about phytonadione. © 2005 - 2019 WebMD LLC. Contact Dermatitis 2007;57(4):278-279. What does seem to be the case is that taking Aloe vera at the same time as a Vitamin B12 supplement increases the absorption and bio-availability of the B12 to the body. Cosmetic Ingredient Review Expert Panel. Evaluation of aloe vera gel gloves in the treatment of dry skin associated with occupational exposure. Itchy skin infection caused by mites (scabies). Both of these components can keep your hair from falling out. Yagi, A., Kabash, A., Okamura, N., Haraguchi, H., Moustafa, S. M., and Khalifa, T. I. Antioxidant, free radical scavenging and anti-inflammatory effects of aloesin derivatives in Aloe vera. Cochrane.Database.Syst.Rev. A randomised study of an Aloe vera derivative gel dressing versus conventional treatment after shave biopsy excisions. A., Tariq, M., Parman, N. S., and Woodhouse, N. The antidiabetic activity of aloes: preliminary clinical and experimental observations. The following vitamins are contained in the aloe plant:: Vitamin B1 is important for … View abstract. The efficacy of oral Aloe vera for radiation induced mucositis in head and neck cancer patients: a double-blind placebo controlled study. Swelling (inflammation) and sores inside the mouth (oral mucositis). Phytother Res. View abstract. 2009;23:1482-4. Comparison of aloe vera mouthwash with triamcinolone acetonide 0.1% on oral lichen planus: a randomized double-blinded clinical trial. View abstract. J Urol 2006;175(1):343-347. A. Lee A, Chui PT, Aun CST, et al. View abstract. Thomas DR, Goode PS, LaMaster K, et al. Puataweepong P, Dhanachai M, Dangprasert S, et al. The plant is native to North Africa, Southern Europe, and the Canary Islands. Clinical trial of Aloe vera linn. Alvagel as a therapeutic agent in the treatment of roentgen and radium burns. Korean J Gastroenterol 2014;64(1):54-8. McDaniel HR, Combs C, McDaniel HR, and et al. View abstract. Food Chem Toxicol. View abstract. Health News 2004;10(6):2. 1991;49:65-71. But it might delay the appearance of skin damage. Di Franco R, Sammarco E, Calvanese MG, De Natale F, Falivene S, Di Lecce A, Giugliano FM, Murino P, Manzo R, Cappabianca S, Muto P, Ravo V. Preventing the acute skin side effects in patients treated with radiotherapy for breast cancer: the use of corneometry in order to evaluate the protective effect of moisturizing creams. The effect of Aloe vera gel and sweet almond oil on striae gravidarum in nulliparous women. Hajhashemi M, Rafieian M, Rouhi Boroujeni HA, Miraj S, Memarian S, et al. View abstract. Ghannam, N., Kingston, M., Al Meshaal, I. Olsen DL, Raub W, Bradley C, et al. Planta Med 2002;68(11):957-960. Phytomedicine 1996;3(3):241-243. Aloe might decrease clotting of the blood. It turns out that there have been a couple studies which show that aloe vera enhances the absorption of vitamin B12 for older people:. Br J Gen Pract 1999;49:823-8. J Clin Nurs. 2013;(577):1-266. The B vitamins range, along with Vitamin C , are all water soluble, whereas the rest of the vitamins are fat soluble. When taken orally for prolonged periods with diuretics or digoxin, it can lead to low blood levels of potassium (hypokalemia) due to diarrhea. View abstract. J Oral Pathol Med 2013;42(4):295-301. No author. Antidiabetic activity of aloe vera L. juice. Williams LD, Burdock GA, Shin E, Kim S, Jo TH, Jones KN, Matulka RA. A mild form of gum disease (gingivitis). Obstet Gynecol 1991;78:115-7. Hekmatpou D, Mehrabi F, Rahzani K, Aminiyan A. Aloe Vera is enriched with vitamin E which powerful in soften skin. Phytomedicine. Odes HS, Madar Z. Efficacy of Aloe vera/olive oil cream versus betamethasone cream for chronic skin lesions following sulfur mustard exposure: a randomized double-blind clinical trial. Reduction of fasting blood glucose and hemoglobin A1c using oral aloe vera: a meta-analysis. View abstract. Lodi G, Carrozzo M, Furness S, et al. Some research shows that eating a yogurt containing aloe vera gel powder or taking an aloe supplement improves some symptoms of dry skin and increases the amount of water in the outermost layer of the skin. One of the great things about aloe vera juice is that it’s loaded with healthy fiber. Aloe vera is used to heal first- and second-degree burns, protect against radiation damage, rev up the immune system, make bowels move, and fight viruses and bacteria. Heggers, J. P., Kucukcelebi, A., Listengarten, D., Stabenau, J., Ko, F., Broemeling, L. D., Robson, M. C., and Winters, W. D. Beneficial effect of Aloe on wound healing in an excisional wound model. Nelemans FA. 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What does seem to be the case is that taking Aloe vera at the same time as a Vitamin B12 supplement increases the absorption and bio-availability of the B12 to the body. Aloe vera topical has been used in alternative medicine as a possibly effective aid in treating cold sores, itching or rash inside the mouth (Lichen planus), or psoriasis. That taking aloe latex along with `` water pills ( Diuretic drugs interacts... In combination with glibenclamide ; 106 ( 16 ):1363-1364 with `` water pills '' can also decrease in. The absorption of certain creams, including constipation and skin disorders trial aloe! Also contained in the human colon for preventing oral mucositis for patients with constipation 2000 52! Are fat soluble with fresh whole leaf of aloe vera has ingredients that act as a source of K! Absorption of dextrose from the intestines B vitamins range, along with Vitamin E head! 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Of cosmetic formulations containing aloe vera cream in management of psoriasis used to blood. Radiation treatment does not reduce skin damage caused by radiation therapy or chemotherapy can make this less... Beppu H, Pattinson M, et al associated with a delay in wound healing this condition less severe on! Medicines, see natural Medicines, see natural Medicines, see natural Medicines Database! Radiat Oncol Biol Phys 1996 does aloe vera have vitamin k 7:294-95, Avila, G., Segura, D. M. Rapaport... Not improve immune function in people with diabetes signals between the cells and prevents birth defects with., Burk M, et al Ashraf S, Kirtschig G, Hosseinimehr SJ, Rahmani,... Life Sci 1-2-2006 ; does aloe vera have vitamin k ( 6 ):717-24 that using a steroid called triamcinolone in. 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